This white paper describes a modular, scale-out solution architecture composed of Parabricks application software, NVIDIA DGX-1 system and Dell EMC Isilon network-attached storage (NAS)capable of analyzing the daily output of an Illumina NovaSeq 6000 Sequencing system, or approximately 24, 40X whole human genomes sequences (WGS) per day. This solution architecture can scale-out to process over 1000 WGS per week. This paper also highlights variables to consider when building out a technical computing environment designed to accelerate the secondary analysis of NGS data.
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